Database / Awards
Federal awards
Every contract and grant ingested from USAspending.gov. Pick an agency to narrow the list; toggle Highest / Lowest to sort. Click any row to open the full award profile.
Sort by
Agency: Department of Health and Human Services
Results
1,640 awards
Showing 1051–1100
| Action date | Recipient | Agency | Amount | Description | Sector |
|---|---|---|---|---|---|
| 2026-04-06 | THE MEDICAL COLLEGE OF WISCONSIN, INC. | Department of Health and Human Services | $70,347,724 | BLOOD AND MARROW TRANSPLANT CLINICAL TRIALS NETWORK DATA COORDINATING CENTER | biotech |
| 2026-04-20 | HAWAII DEPARTMENT OF HEALTH | Department of Health and Human Services | $70,200,164 | CDC-RFA-IP19-1901 IMMUNIZATION AND VACCINES FOR CHILDREN | health |
| 2026-03-10 | HEALTH CARE SERVICE CORPORATION, A MUTUAL LEGAL RESERVE COMPANY | Department of Health and Human Services | $70,140,400 | IHS PURCHASED REFERRED CARE (PRC) FISCAL INTERMEDIARY (FI) SERVICES | health |
| 2026-05-05 | IA DEPARTMENT OF HUMAN SERVICES | Department of Health and Human Services | $70,127,831 | CCDD-2026 - CHILD CARE AND DEVELOPMENT BLOCK GRANT DISCRETIONARY | social-services |
| 2026-04-20 | NEVADA DEPARTMENT OF HEALTH AND HUMAN SERVICES | Department of Health and Human Services | $70,121,223 | RYAN WHITE CARE ACT TITLE II | health |
| 2026-04-20 | CITY OF HOUSTON | Department of Health and Human Services | $70,112,232 | CDC-RFA-IP19-1901 IMMUNIZATION AND VACCINES FOR CHILDREN | health |
| 2026-04-06 | CHILDREN & FAMILY SERVICES, NEW YORK OFFICE OF | Department of Health and Human Services | $69,989,382 | SSBG-2026 - SOCIAL SERVICES BLOCK GRANT | social-services |
| 2026-04-20 | TENNESSEE HOUSING DEVELOPMENT AGENCY | Department of Health and Human Services | $69,833,695 | LIHEAP-2026 - LOW INCOME HOME ENERGY ASSISTANCE | social-services |
| 2026-04-06 | SOCIAL SERVICES SOUTH DAKOTA DEPARTMENT | Department of Health and Human Services | $69,799,655 | MEDICAID ENTITLEMENT FOR 51 - FY 2026 - T19 | social-services |
| 2026-04-20 | ST. JOHN'S COMMUNITY HEALTH | Department of Health and Human Services | $69,768,813 | HEALTH CENTER CLUSTER | health |
| 2026-03-05 | CAGUAS MUNICIPALITY | Department of Health and Human Services | $69,683,550 | HEAD START AND EARLY HEAD START | social-services |
| 2026-03-05 | CHERRY STREET SERVICES INC | Department of Health and Human Services | $69,220,328 | HEALTH CENTER CLUSTER | health |
| 2026-03-20 | DEPARTMENT OF COMMUNITY SERVICES & DEVELOPMENT CALIFORNIA | Department of Health and Human Services | $68,785,179 | CSBG-2024 | social-services |
| 2026-03-20 | ARIZONA DEPARTMENT OF ECONOMIC SECURITY | Department of Health and Human Services | $68,742,680 | CCDF-2022 | social-services |
| 2026-05-05 | E CENTER | Department of Health and Human Services | $68,730,256 | HEAD START AND EARLY HEAD START | social-services |
| 2026-04-20 | COLLIER HEALTH SERVICES INC | Department of Health and Human Services | $68,448,560 | HEALTH CENTER CLUSTER | health |
| 2026-05-05 | DEPARTMENT OF EARLY LEARNING AND CARE | Department of Health and Human Services | $68,405,385 | CCDD-2026 - CHILD CARE AND DEVELOPMENT BLOCK GRANT DISCRETIONARY | social-services |
| 2026-04-20 | POTENTIA NAMIBIA RECRUITMENT (PTY) LTD | Department of Health and Human Services | $68,391,046 | ASSISTING THE MOHSS IN PROVIDING CRITICAL HUMAN RESOURCES FOR HEALTH FOR EMERGENCY PREPAREDNESS AND TO ACHIEVE HIV EPIDEMIC CONTROL IN NAMIBIA UNDER THE U.S. PEPFAR - ALIGNED WITH THE ULTIMATE GOAL OF ACHIEVING AN AIDS-FREE NAMIBIAN GENERATION, AS DEFINED IN NAMIBIA?S NATIONAL STRATEGIC FRAMEWORK (NSF) FOR HIV/AIDS RESPONSE, THE CURRENT APPLICATION DETAILS THE APPLICANT?S PLANNED STRATEGIES AND ACTIVITIES TO ASSIST THE MINISTRY OF HEALTH AND SOCIAL SERVICES (MOHSS) IN NAMIBIA, THROUGH THE PROVISION OF CRITICAL HUMAN RESOURCES FOR HEALTH (HRH) SERVICES AND SUPPORT, INCLUDING THE RECRUITMENT OF HRH STAFF FOR PROJECT ACTIVITIES, STRENGTHENING THE MOHSS? CAPACITY FOR HR MANAGEMENT, SUPPORTING THE RETENTION OF COMPETENT PUBLIC HEALTH STAFF FOR PROJECT ACTIVITIES, AND DEVELOPING A SUSTAINABILITY PLAN FOR THE TRANSITIONING OF DONOR-FUNDED HRH FUNCTIONS TO THE NAMIBIAN GOVERNMENT. THE APPLICANT DEMONSTRATES THE WAY IN WHICH ITS? HRH SERVICES WILL AUGMENT THE MOHSS? CAPACITY TO MANAGE HRH AND BETTER EQUIP THE MOHSS TO ACHIEVE ITS GREATER GOALS, INCLUDING REACHING THE 95-95-95 TARGET SET BY THE WORLD HEALTH ORGANIZATION (WHO), MEETING THE PRESIDENT?S EMERGENCY PLAN FOR AIDS RELIEF (PEPFAR) OBJECTIVES, ACHIEVING HIV EPIDEMIC CONTROL (HEC), AND IMPROVING NAMIBIA?S OVERALL PUBLIC HEALTH PREPAREDNESS. A PROJECT LOGIC MODEL, WITH VARIOUS INDICATORS ALIGNED TO THE MAIN GOAL AND OBJECTIVES, HAS BEEN PROVIDED TO MEASURE OUTCOMES MONTHLY, QUARTERLY, AND ANNUALLY. THE APPLICANT HAS DEVELOPED AN EVALUATION AND PERFORMANCE MANAGEMENT PLAN, WHICH OUTLINES PROGRAM IMPLEMENTATION AND PERFORMANCE MONITORING AND EVALUATION ACTIVITIES, FOR THE DURATION OF THE PROJECT. ACCORDING TO THIS PLAN, EACH STRATEGY WILL BE INDIVIDUALLY ASSESSED BASED ON INDICATORS, WITH VARYING DEGREES OF CLARITY BY ENGAGING WITH THE MOHSS. TO DEMONSTRATE EFFECTIVENESS AND EFFICIENCY OF HRH SERVICES IN MOHSS, THE APPLICANT WILL CONDUCT BOTH PROCESS EVALUATIONS AND OUTCOME EVALUATIONS. THE APPLICANT HAS DEVELOPED A DATA MANAGEMENT PLAN, WHICH WILL BE USED TO RECORD DATA AND EFFECTIVE DISSEMINATION OF EVALUATION RESULTS WILL BE ACHIEVED THROUGH PRESENTATIONS OF PRO GRAM EVALUATION REPORTS TO THE MOHSS AND CENTERS FOR DISEASE CONTROL AND PREVENTION (CDC). A WORK PLAN, WHICH INCORPORATES THE REQUIRED ACTIVITIES AND OUTCOMES, HAS BEEN DEVELOPED BY THE APPLICANT FOR THE FIRST YEAR OF FUNDING TOGETHER WITH AN ABRIDGED WORK PLAN FOR THE FOUR SUBSEQUENT YEARS OF FUNDING. THE PROVISION OF TARGETED SUPPORT WITHIN THE IDENTIFIED PRIORITY REGIONS, KHOMAS, OMUSATI, OSHANA, OHANGWENA, OSHIKOTO, ZAMBEZI, AND KAVANGO EAST AND WEST, HAS BEEN PLANNED. THE APPLICANT HAS DRAFTED AN ACCOMPANYING BUDGET, WHICH FALLS WITHIN THE APPROVED LIMITS OF FUNDING. THE APPLICANT HAS DEMONSTRATED ITS ORGANIZATIONAL CAPACITY TO IMPLEMENT THE APPROACH BY HIGHLIGHTING ITS EXPERIENCE IN ALL ASPECTS OF PERSONNEL MANAGEMENT AND LABOR RELATIONS AS WELL AS ITS EXTENSIVE INSIGHTS, EXPERIENCE, ESTABLISHED PROCESSES AND METHODOLOGIES TO EFFECTIVELY MANAGE THE REQUIREMENTS OF UNITED STATES GOVERNMENT (USG)-FUNDING RESPONSIBILITIES AND REPORTING. THE APPLICANT HAS ALSO DEMONSTRATED ITS COLLABORATIVE SKILLS AND ABILITY THROUGH ITS PARTNERSHIPS AND EXPERIENCE WORKING WITH CDC PROGRAMS AND CDC-FUNDED ORGANIZATIONS AS WELL AS OTHER ORGANIZATIONS AND LOCAL AND FOREIGN HEALTH EXPERTS. THE APPLICANT HAS ILLUSTRATED HOW ITS SKILL-, KNOWLEDGE-, AND COMPETENCY-BASE AS WELL AS ITS ADAPTABILITY, DYNAMIC FRAMEWORK, RAPID DECISION-MAKING CAPABILITY, FINANCIAL ABILITY, AND ITS EFFECTIVE ORGANIZATIONAL SIZE, PRESENCE, AND REACH RENDERS IT AN EFFECTIVE CONDUIT THROUGH WHICH PEPFAR FUNDING CAN BE CHANNELED TO ACHIEVE MAXIMUM IMPACT WITHIN A LIMITED TIME FRAME.THE APPLICANT HAS DEMONSTRATED FULL COMPLIANCE WITH THE CDC NOTICE OF FUNDING OPPORTUNITY (NOFO) STATUTORY REQUIREMENTS AND DISCLOSURES. THE APPLICANT IS AN ENTITY OTHER THAN A SOLE PROPRIETORSHIP AND IS INCORPORATED IN THE REPUBLIC OF NAMIBIA. IT IS A COMPANY FULLY OWNED BY NAMIBIAN CITIZE | health |
| 2026-05-12 | PFIZER INC | Department of Health and Human Services | $68,359,693 | IGF::OT::IGF | biotech |
| 2026-04-20 | HEALTH, LOUISIANA DEPARTMENT OF | Department of Health and Human Services | $68,217,015 | STRENGTHENING LOUISIANA?S PUBLIC HEALTH INFRASTRUCTURE, WORKFORCE, AND DATA SYSTEMS - STRENGTHENING LOUISIANA’S PUBLIC HEALTH INFRASTRUCTURE, WORKFORCE, AND DATA SYSTEMS | health |
| 2026-05-05 | COASTAL FAMILY HEALTH CENTER INC | Department of Health and Human Services | $68,195,229 | HEALTH CENTER CLUSTER | health |
| 2026-02-20 | CHILDRENS INSTITUTE INC | Department of Health and Human Services | $68,176,037 | HEAD START AND EARLY HEAD START | social-services |
| 2026-04-06 | MARYLAND DEPARTMENT OF HUMAN SERVICES | Department of Health and Human Services | $68,170,994 | SCSS-2026 - CHILD SUPPORT SERVICES - STATES | social-services |
| 2026-04-20 | PHILIPS NORTH AMERICA LLC | Department of Health and Human Services | $68,167,100 | THIS SYSTEM WOULD BE USED AND INTEGRATED WITHIN ROUTINE CARE FOR BURNS AND TRAUMATIC INJURIES, BUT WOULD ALSO HAVE THE POTENTIAL TO BE OF USE IN DETECTION VIRAL PNEUMONIA OF COVID 19 CASES. | health |
| 2026-03-20 | RUTGERS THE STATE UNIVERSITY OF NEW JERSEY | Department of Health and Human Services | $68,162,976 | CANCER CENTER SUPPORT GRANT | biotech |
| 2026-04-06 | STATE OF WISCONSIN DEPARTMENT OF HEALTH SERVICES | Department of Health and Human Services | $68,104,785 | THIS AWARD WILL BE A CONTINUATION OF FUNDS INTENDED ONLY FOR RECIPIENTS PREVIOUSLY AWARDED UNDER OE22-2203 - WISCONSIN’S PUBLIC HEALTH SYSTEM HAS BEEN CRITICALLY UNDER-RESOURCED FOR DECADES. TO ADDRESS THESE GAPS, THE WISCONSIN DIVISION OF PUBLIC HEALTH (DPH) WILL USE GRANT FUNDS TO BOLSTER THE IMPLEMENTATION OF THE FOUNDATIONAL PUBLIC HEALTH SERVICES (FPHS) MODEL ACROSS THE STATE, INCLUDING: (1) REFINING OUR DEFINITION OF CORE PUBLIC HEALTH SERVICES MORE CONCRETELY IN FPHS TERMS; (2) QUANTIFYING THE RESOURCES AND STAFF REQUIRED TO IMPLEMENT THEM; AND (3) ADDRESSING IDENTIFIED GAPS THROUGH STRATEGIC POSITIONS THAT PROVIDE NEEDED TRAINING, SKILLS DEVELOPMENT, AND APPLICATION OPPORTUNITIES. A HIGH-LEVEL SUMMARY OF THE WORK WE PROPOSE UNDERTAKING IS OUTLINED BELOW. CROSS-CUTTING ACTIVITIES IN YEAR 1, DPH WILL CONDUCT A SYSTEM-WIDE ASSESSMENT OF THE PUBLIC HEALTH SYSTEM, INCLUDING STATE, LOCAL AND TRIBAL HEALTH DEPARTMENT (LTHD) STRUCTURE, FINANCING, STAFFING, SALARIES, WORKFORCE WELLBEING AND JOB SATISFACTION, CORE COMPETENCIES, AND CAPACITY TO PROVIDE FOUNDATIONAL CAPABILITIES. IN LATER YEARS, DPH WILL ALSO WORK WITH A CONTRACTOR TO QUANTIFY THE ECONOMIC AND HUMAN IMPACTS OF GOVERNMENTAL PUBLIC HEALTH. A1. WORKFORCE DPH’S WORKFORCE GOAL IS TO ASSURE A WELL-TRAINED, SKILLED, MOTIVATED, AND ADAPTABLE WORKFORCE, CAPABLE OF PROVIDING THE FOUNDATIONAL CAPABILITIES. TOWARDS ACHIEVING THIS GOAL, DPH WILL HIRE 48 STRATEGIC POSITIONS THAT FOCUS ON RAISING STAFF CAPACITY FOR THE FOUNDATIONAL CAPABILITIES ACROSS DPH AND LTHD PARTNERS. PROPOSED ACTIONS INCLUDE STRENGTHENING AND ESTABLISHING PARTNERSHIPS WITH ACADEMIC AND NON-ACADEMIC RECRUITMENT PIPELINES; CHANGING RECRUITING AND HIRING PRACTICES TO FOSTER GREATER DIVERSITY, EQUITY, AND INCLUSION; PARTNERING WITH HR TO EXPLORE RETENTION-RELATED TOPICS (E.G., PAY EQUITY, REMOTE WORK POLICIES, ETC.); ENACTING MECHANISMS TO RESPOND TO PROFESSIONAL TRAUMA AND BURN-OUT; AND PROVIDING TARGETED TRAINING TO STAFF IN CORE COMPETENCY GAPS, AMONG OTHERS. ADDITIONALLY, 40% OF A1 FUNDING WILL BE ALLOCATED TO LTHD PARTNERS. A2. FOUNDATIONAL CAPABILITIES DPH’S APPROACH FOR FOUNDATIONAL CAPABILITIES FOCUSES ON CREATING THE CONDITIONS NEEDED TO STRENGTHEN WORKFORCE SKILLS AND CAPACITIES IN THE FACE OF SIGNIFICANT TURNOVER AND LOSS OF INSTITUTIONAL KNOWLEDGE. THESE ACTIVITIES INCLUDE DEVELOPING AND COSTING THE WISCONSIN FPHS MODEL, COMPLETING REACCREDITATION FOR THE STATE OF WISCONSIN, PROVIDING TRAINING IN THE CORE COMPETENCIES AND FOUNDATIONAL CAPABILITIES TO STATE AND LOCAL STAFF, AND IMPROVING CAPACITY TO COMMUNICATE PUBLIC HEALTH’S ROLE AND IMPACT WITH THE PUBLIC AND KEY PARTNERS. ADDITIONALLY, $150,000/YEAR PLUS TECHNICAL ASSISTANCE AND TARGETED TRAINING WILL BE RESERVED FOR RELATED LTHD PARTNERS. A3. DATA MODERNIZATION THE DPH DATA MODERNIZATION (A3) STRATEGY FOCUSES ON MODERNIZING WISCONSIN DATA SOURCES, STORAGE AND EXCHANGE SYSTEMS, AND WORKFORCE CAPABILITIES USED TO INFORM DECISION-MAKING AND FACILITATE THE DELIVERY OF EFFECTIVE, TIMELY PUBLIC HEALTH SERVICES AND PROGRAMS. A3 ACTIVITIES INCLUDE INFORMATION-GATHERING WITH KEY STAKEHOLDERS ABOUT DATA SYSTEMS NEEDS, EXCHANGE RELATIONSHIPS, AND DATA SOURCES; DEVELOPING AND CREATING THE DATA MODERNIZATION IMPLEMENTATION PLAN; AND COMPLETING THREE PROJECTS FROM THE DPH DATA MODERNIZATION PORTFOLIO: MODERNIZE THE DATA REQUEST TRACKING SYSTEM, UPDATE THE DATA SOURCES REPOSITORY, AND CREATE A REGIONAL IT INFRASTRUCTURE FOR DELIVERY OF VISUALIZED DATA TO LTHDS. OUTCOMES DPH’S EXPECTED LONG-TERM OUTCOMES INCLUDE A LARGER, MORE EQUIPPED WORKFORCE THAT HAS THE SKILLS NEEDED TO IMPLEMENT THE FOUNDATIONAL CAPABILITIES, WHICH WILL BETTER POSITION THE PUBLIC HEALTH SYSTEM TO MEET WISCONSIN’S PUBLIC HEALTH NEEDS. ADDITIONALLY, WISCONSIN DPH SEEKS TO LEVERAGE A STRONGER SYSTEM AND IMPROVED RETURN-ON-INVESTMENT KNOWLEDGE TO BUILD SUSTAINABLE FISCAL, LOGISTIC, AND LEGISLATIVE SUPPORT FOR THE PUBLIC HEALTH SYSTEM. OVER THE NEXT FIVE YEARS, THESE OUTCOMES WILL ADVANCE WISCONSIN’S LONG-TERM VISION OF A STRONGER, RESILIENT PUBLIC HEALTH SYSTEM. | health |
| 2026-05-05 | NATIONWIDE CHILDRENS HOSPITAL | Department of Health and Human Services | $68,096,674 | CHILDREN'S HOSPITALS GRADUATE MEDICAL EDUCATION PAYMENT PROGRAM | health |
| 2026-03-20 | DEPARTMENT OF HUMAN SERVICES | Department of Health and Human Services | $68,033,001 | ADPTASST-2024 | social-services |
| 2026-04-20 | SOFTRAMS LLC | Department of Health and Human Services | $67,952,878 | BUSINESS OPERATIONS SUPPORT CENTER (BOSC) | health |
| 2026-04-06 | CHEROKEE HEALTH SYSTEMS | Department of Health and Human Services | $67,940,517 | HEALTH CENTER CLUSTER | health |
| 2026-03-20 | LUTHERAN IMMIGRATION AND REFUGEE SERVICE INC | Department of Health and Human Services | $67,806,734 | RESIDENTIAL (SHELTER AND/OR TRANSITIONAL FOSTER CARE) SERVICES FOR UNACCOMPANIED CHILDREN-LICENSED AND TEXAS-EXEMPT AND FLORIDA-DELICENSED ONLY | social-services |
| 2026-04-20 | FRED HUTCHINSON CANCER CENTER | Department of Health and Human Services | $67,679,289 | EARLY DETECTION RESEARCH NETWORK: DATA MANAGEMENT AND COORDINATING CENTER | biotech |
| 2026-04-20 | HEALTH AND HUMAN SERVICES, MAINE DEPARTMENT OF | Department of Health and Human Services | $67,593,409 | CDC-RFA-IP19-1901 IMMUNIZATION AND VACCINES FOR CHILDREN | health |
| 2026-04-20 | DEPARTMENT OF PUBLIC HEALTH CONNECTICUT | Department of Health and Human Services | $67,537,493 | RYAN WHITE CARE ACT TITLE II | health |
| 2026-05-05 | ARKANSAS CHILDRENS HOSPITAL | Department of Health and Human Services | $67,499,027 | CHILDREN'S HOSPITALS GRADUATE MEDICAL EDUCATION PAYMENT PROGRAM | health |
| 2026-05-05 | ZERO TO THREE NATIONAL CENTER FOR INFANTS, TODDLERS & FAMILIES | Department of Health and Human Services | $67,494,269 | NATIONAL CENTER ON EARLY CHILDHOOD DEVELOPMENT, TEACHING, AND LEARNING | social-services |
| 2026-03-20 | HARRIS COUNTY DEPARTMENT OF EDUCATION PUBLIC FACILITY CORPORATION | Department of Health and Human Services | $67,361,526 | HEAD START AND EARLY HEAD START | social-services |
| 2026-05-05 | THE NEW YORK FOUNDLING | Department of Health and Human Services | $67,267,824 | HEAD START AND EARLY HEAD START | social-services |
| 2026-05-05 | GREENE COUNTY HEALTH CARE, INCORPORATED | Department of Health and Human Services | $67,164,968 | HEALTH CENTER CLUSTER | health |
| 2026-04-20 | ILLINOIS DEPARTMENT OF HUMAN SERVICE | Department of Health and Human Services | $67,130,792 | CCDM-2026 - CHILD CARE AND DEVELOPMENT FUND -- STATE MATCHING | social-services |
| 2026-04-06 | POLICE ATHLETIC LEAGUE INC | Department of Health and Human Services | $66,984,660 | HEAD START AND EARLY HEAD START | social-services |
| 2026-04-13 | HUMANTOUCH LLC | Department of Health and Human Services | $66,800,728 | HELP DESK BRIDGE CONTRACT | health |
| 2026-03-20 | DEPARTMENT OF STATE NEW YORK | Department of Health and Human Services | $66,704,626 | CSBG-2024 | social-services |
| 2026-05-05 | CHILDREN'S HOSPITAL OF WISCONSIN, INC. | Department of Health and Human Services | $66,627,975 | CHILDREN'S HOSPITALS GRADUATE MEDICAL EDUCATION PAYMENT PROGRAM | health |
| 2026-04-08 | WASHINGTON SUBURBAN SANITARY COMMISSION | Department of Health and Human Services | $66,593,899 | WSSC (WATER) NIH CAMPUS AND LEASE INVOICING (FY22) CONTRACT# 75N99022C00001 | health |
| 2026-04-06 | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK | Department of Health and Human Services | $66,521,567 | ALZHEIMER'S DISEASE AND ALZHEIMER'S DISEASE RELATED DEMENTIAS IN PREDIABETES AND TYPE 2 DIABETES: THE DIABETES PREVENTION PROGRAM OUTCOMES STUDY AD/ADRD PROJECT - THIS U19 PROPOSAL FOCUSES ON ONE OF THE MOST IMPORTANT, COMPLEX QUESTIONS IN ALZHEIMER’S DISEASE (AD) AND ALZHEIMER’S DISEASE-RELATED DEMENTIAS (ADRD) RESEARCH: WHAT ARE THE DETERMINANTS AND THE NATURE OF COGNITIVE IMPAIRMENT AMONG PERSONS WITH PRE-DIABETES (PRED) AND TYPE 2 DIABETES (T2D), WHO ARE A HIGH-RISK GROUP FOR COGNITIVE IMPAIRMENT AND REPRESENT A LARGE FRACTION OF THE UNITED STATES (US) POPULATION? DESPITE KNOWLEDGE THAT PERSONS WITH PRED AND T2D ARE A HIGH-RISK GROUP FOR COGNITIVE DECLINE, MILD COGNITIVE IMPAIRMENT (MCI), AND DEMENTIA, THE RISK FACTORS, MECHANISMS, AND NEUROPATHOLOGY OF COGNITIVE IMPAIRMENT IN PERSONS WITH PRED AND T2D REMAIN UNCLEAR. GAPS IN KNOWLEDGE ON COGNITIVE IMPAIRMENT IN PRED AND T2D INCLUDE: (A) THE ROLE OF AD AND/OR NON-AD NEUROPATHOLOGY BEYOND VASCULAR CONTRIBUTIONS TO COGNITIVE IMPAIRMENT AND DEMENTIA (VCID); (B) THE ROLE OF GLYCEMIA, RELATED METABOLIC FACTORS SUCH AS HYPERINSULINEMIA, AND TRADITIONAL MICRO AND MACROVASCULAR COMPLICATIONS OF PRED/T2D; (C) THE ROLE OF GLUCOSE-LOWERING MEDICATIONS, PRIMARILY METFORMIN; AND (D) THE ROLE OF PHYSICAL ACTIVITY, PHYSICAL FUNCTION, AND FRAILTY, KEY IN PRED AND T2D. WE PROPOSE 4 INTERRELATED PROJECTS THAT WILL ADDRESS THESE GAPS, LEVERAGING THE DIABETES PREVENTION PROGRAM (DPP) OUTCOMES STUDY (DPPOS) COHORT AND ITS DETAILED PRED/T2D PHENOTYPING, ADDING STATE OF THE ART AD/ADRD PHENOTYPING. THE DPPOS COHORT CURRENTLY HAS A MEAN AGE OF 72 YEARS, WITH 76% OVER THE AGE OF 65. THUS, THE COHORT IS IN A PERIOD OF THE LIFESPAN WHEN THE DEVELOPMENT OF COGNITIVE DECLINE, MCI, AND DEMENTIA ACCELERATES. THIS EXTENSIVELY PHENOTYPED COHORT REPRESENTS AN ESTIMATED 50 MILLION AMERICANS. TO ADDRESS THIS PROPOSAL’S COMPLEX INTERRELATED QUESTIONS, WE WILL PERFORM TWO WAVES OF STATE-OF-THE-ART AD/ADRD PHENOTYPING DURING THE PROPOSED 5-YEAR FUNDING PERIOD, INCLUDING COMPREHENSIVE COGNITIVE ASSESSMENTS AND SYNDROME ADJUDICATION AND PLASMA AND BRAIN IMAGING BIOMARKERS OF AD/ADRD. WE WILL ADDRESS THE COMPLEX OVERARCHING QUESTION OF OUR PROJECT THROUGH THE FOLLOWING AIMS: (1) TO ESTABLISH 5 CORES TO SUPPORT THE 4 INTEGRATED SCIENTIFIC PROJECTS: AN ADMINISTRATIVE CORE, A CLINICAL OPERATIONS AND PROCEDURES CORE, A COGNITIVE ASSESSMENT AND ADJUDICATION CORE, A NEUROIMAGING AND PLASMA BIOMARKERS CORE, AND A BIOSTATISTICS AND DATA INFRASTRUCTURE CORE: (2) TO CONDUCT 4 INTEGRATED PROJECTS FOCUSED ON KEY ASPECTS OF THE CENTRAL QUESTION OF THIS PROPOSAL: PROJECT 1 WILL EXAMINE THE ASSOCIATION OF COGNITIVE DECLINE, MCI, AND DEMENTIA IN THE DPPOS COHORT WITH BIOMARKERS OF NEUROPATHOLOGY AND BRAIN INSULIN SIGNALING, AND WITH SOCIODEMOGRAPHIC AND BEHAVIORAL FACTORS; PROJECT 2 WILL EXAMINE THE ASSOCIATIONS OF CUMULATIVE GLYCEMIA, RELATED METABOLIC FACTORS, AND MICROVASCULAR AND MACROVASCULAR COMPLICATIONS, WITH COGNITIVE SYNDROMES AND BIOMARKERS OF NEUROPATHOLOGY; PROJECT 3 WILL EXAMINE THE ASSOCIATION OF CUMULATIVE EXPOSURE TO METFORMIN AND OTHER T2D MEDICATIONS WITH COGNITIVE SYNDROMES AND BIOMARKERS OF NEUROPATHOLOGY; PROJECT 4 WILL EVALUATE THE ASSOCIATION OF TRAJECTORIES OF PHYSICAL ACTIVITY, PHYSICAL FUNCTION AND FRAILTY WITH COGNITIVE SYNDROMES AND BIOMARKERS OF NEUROPATHOLOGY. | biotech |
| 2026-02-27 | THE RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK | Department of Health and Human Services | $66,342,260 | WTCHP CLINICAL CENTERS OF EXCELLENCE | health |
| 2026-03-20 | ILLINOIS DEPARTMENT OF HUMAN SERVICE | Department of Health and Human Services | $66,247,897 | SUBSTANCE ABUSE PREVENTION, TREATMENT, AND RECOVERY SERVICES BLOCK GRANT | health |
| 2026-04-20 | UPPER EAST TENNESSEE HUMAN DEVELOPMENT AGENCY, INC. | Department of Health and Human Services | $66,238,350 | HEAD START | social-services |
| 2026-03-05 | OAKLAND LIVINGSTON HUMAN SERVICE AGENCY | Department of Health and Human Services | $66,139,451 | HEAD START AND EARLY HEAD START | social-services |
Page 22 of 33