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Federal awards
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Agency: Department of Health and Human Services
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1,640 awards
Showing 1201–1250
| Action date | Recipient | Agency | Amount | Description | Sector |
|---|---|---|---|---|---|
| 2026-04-06 | NEW YORK UNIVERSITY | Department of Health and Human Services | $60,745,274 | CANCER CENTER SUPPORT GRANT | biotech |
| 2026-04-20 | COMMERCE, WASHINGTON STATE DEPARTMENT OF | Department of Health and Human Services | $60,706,949 | LIHEAP-2026 - LOW INCOME HOME ENERGY ASSISTANCE | social-services |
| 2026-04-20 | REGENTS OF THE UNIVERSITY OF CALIFORNIA, SAN FRANCISCO, THE | Department of Health and Human Services | $60,700,604 | THE ALZHEIMER'S DISEASE TAU PLATFORM CLINICAL TRIAL - PROJECT SUMMARY / ABSTRACT TAU PROTEIN IS AN ATTRACTIVE AD THERAPEUTIC TARGET BECAUSE THE AMOUNT AND ANATOMICAL DISTRIBUTION OF INSOLUBLE TAU AT AUTOPSY IS STRONGLY CORRELATED WITH THE SYMPTOMS AND SEVERITY OF DISEASE DURING LIFE. MULTIPLE TAU THERAPIES ARE NOW IN CLINICAL TRIALS FOR AD, WITH MANY NEW AGENTS ENTERING THE CLINIC. NEW APPROACHES TO ACCELERATING THEIR CLINICAL DEVELOPMENT ARE URGENTLY NEEDED. A VARIETY OF AD BIOMARKERS NOW EXIST, INCLUDING CSF AND PLASMA BETA AMYLOID RATIOS AND PHOSPHORYLATED TAU (P-TAU) LEVELS, AND AMYLOID AND TAU PET TRACERS, PROVIDING TOOLS TO MEASURE PHARMACODYNAMIC EFFECTS OF AMYLOID AND TAU THERAPIES ON THE CORE BIOLOGY OF AD. THE GOAL OF THE ALZHEIMER’S TAU PLATFORM (ATP) TRIAL IS TO CONDUCT A RANDOMIZED, PLACEBO CONTROLLED, PHASE 2 PLATFORM TRIAL IN PRECLINICAL-PRODROMAL AD THAT WILL SIMULTANEOUSLY TEST AT LEAST TWO DIFFERENT TAU-DIRECTED THERAPIES, ALONE OR IN COMBINATION WITH AN ANTI-AMYLOID THERAPY, TO DETERMINE SAFETY, TOLERABILITY, AND BIOLOGICAL BASED PROOF OF CONCEPT BASED ON THE TAU PET TRACER 18F MK6240 AND OTHER TAU BIOMARKERS. PLATFORM TRIALS CREATE EFFICIENCIES THROUGH GENERATION OF A COMMON CLINICAL TRIAL PROTOCOL AND SHARED PLACEBO GROUPS TO ALLOW A GREATER NUMBER OF THERAPIES TO BE TESTED IN LESS TIME WITH LESS EXPENSE THAN BY CONDUCTING MULTIPLE INDEPENDENT TRIALS. THIS TRIAL WILL TEST 5 THERAPEUTIC HYPOTHESES INVOLVING COMBINATIONS OF 3 DRUGS VERSUS PLACEBO: TWO TAU THERAPIES WILL BE STUDIED IN A 2 X 3 FACTORIAL DESIGN (PLACEBO VS. ANTI-AMYLOID [N=2] X TWO TAU THERAPIES OR PLACEBO [N=3]) FOR 24 MONTHS, IN SIX PARALLEL ARMS. THE KEY INCLUSION CRITERIA FOR ATP WILL BE >20 CENTILOIDS OF AMYLOID PET UPTAKE, 18F MK6240 TEMPORAL ROI SUVR >1.25, WITH A GLOBAL CLINICAL DEMENTIA RATING (CDR) OF 0 OR 0.5 AND MMSE >23. USING THESE CRITERIA, WE ESTIMATE THAT 150 PARTICIPANTS PER ARM WILL BE NECESSARY TO HAVE 80% POWER TO DETECT A 30% SLOWING IN THE ACCUMULATION 18F MK6240 SIGNAL OVER 24 MONTHS OF BLINDED THERAPY. KEY SECONDARY ENDPOINTS WILL BE CHANGES IN PLASMA P-TAU SPECIES (-217, ETC.) AND NEUROFILAMENT LIGHT CHAIN (NFL), CLINICAL RATING SCALES AND VOLUMETRIC MRI. LEVERAGING THE EXPERIENCE AND RESOURCES OF THE NIH AD CLINICAL TRIAL CONSORTIUM (ACTC), WE PROPOSE TO ENROLL 900 PARTICIPANTS AT ~100 ACTC SITES OVER 24 MONTHS, RANDOMIZE THEM 5:1 DRUG:PLACEBO FOR 24 MONTHS OF BLINDED TREATMENT, FOLLOWED BY A 24 MONTH OPEN LABEL EXTENSION. WE AIM TO: 1) TEST THE ABILITY OF TWO TAU-DIRECTED THERAPIES, EITHER ALONE OR IN COMBINATION WITH AN ANTI-AMYLOID THERAPY, TO SLOW THE ACCUMULATION OF TAU PET SIGNAL OVER 24 MONTHS AS COMPARED TO PLACEBO OR ANTI-AMYLOID THERAPY ALONE; 2) TEST THE SAFETY AND TOLERABILITY OF 24 MONTHS OF BLINDED THERAPY FOLLOWED BY AN OPTIONAL 24 MONTH OPEN LABEL EXTENSION OF COMBINATION TAU/ANTI-AMYLOID THERAPY; AND 3) EXPLORE THE ABILITY OF EACH OF TWO TAU DIRECTED THERAPIES TO SLOW DISEASE PROGRESSION AS MEASURED BY CSF AND PLASMA BIOMARKERS (PLASMA P-TAU, NFL), VOLUMETRIC MRI AND CLINICAL ASSESSMENTS (PRECLINICAL ALZHEIMER’S COMPOSITE [PACC], ETC.). IF SUCCESSFUL, THE ATP WILL PROVIDE DATA FOR DECISION-MAKING ABOUT WHICH TAU THERAPIES OR COMBINATIONS TO PURSUE IN LARGER EFFICACY STUDIES, AN ONGOING RESOURCE TO TEST NEW THERAPEUTIC APPROACHES BEYOND TAU, AND WILL IMPROVE UNDERSTANDING OF AD BIOLOGY. | health |
| 2026-04-20 | STATE OF RHODE ISLAND DEPARTMENT OF HEALTH | Department of Health and Human Services | $60,687,199 | RHODE ISLAND IMMUNIZATION AND VACCINES FOR CHILDREN COVID SUPPLEMENTAL | health |
| 2026-04-06 | LOUISIANA HOUSING CORPORATION | Department of Health and Human Services | $60,669,679 | LIHEAP-2024 | social-services |
| 2026-04-22 | U.S. COMMITTEE FOR REFUGEES AND IMMIGRANTS, INC. | Department of Health and Human Services | $60,663,512 | RESIDENTIAL (SHELTER AND/OR TRANSITIONAL FOSTER CARE) SERVICES FOR UNACCOMPANIED CHILDREN - LICENSED AND TEXAS-EXEMPT AND FLORIDA-DELICENSED ONLY | social-services |
| 2026-03-20 | NEW HAMPSHIRE DEPARTMENT OF HEALTH & HUMAN SERVICES | Department of Health and Human Services | $60,655,445 | STATE OPIOID RESPONSE - THROUGH THE NH STATE OPIOID RESPONSE (SOR) 2024, THE NH DEPARTMENT OF HEALTH AND HUMAN SERVICES WILL INCREASE SERVICES FOR YOUTH AND ADULTS WITH OR AT RISK OF DEVELOPING A SUBSTANCE USE DISORDER (SUD) STATEWIDE. THE CONTINUED FOCUS OF SOR IN NH WILL BE IN ALL REGIONS OF THE STATE, CONTINUING TO CREATE ACCESS TO PREVENTION, HARM REDUCTION, TREATMENT, AND RECOVERY FOR PEOPLE WITH ALL TYPES OF SUBSTANCE USE, SPECIFICALLY FOCUSED ON OPIOID USE DISORDER AND STIMULANT USE DISORDER (O/STIMUD), AS WELL AS ADDRESSING ASSOCIATED CO-MORBIDITIES SUCH AS MENTAL HEALTH, AND PHYSICAL HEALTH, INCLUSIVE OF INFECTIOUS DISEASES. WHILE SERVICES WILL BE MADE AVAILABLE TO ANYONE SEEKING ASSISTANCE IN NH, SPECIAL POPULATIONS WILL REMAIN A PRIORITY. THESE SPECIAL POPULATIONS INCLUDE YOUTH AND YOUNG ADULTS (16-25 YEARS OLD) AND THEIR FAMILIES; OLDER ADULTS; PREGNANT AND PARENTING PEOPLE; INDIVIDUALS WITH OR AT RISK OF HIV/AIDS; THE LGBTQA+ COMMUNITY; CHILDREN, YOUTH AND FAMILIES IMPACTED BY SUD, INCLUDING KINSHIP AND FOSTER CARE FAMILIES; INDIVIDUALS INVOLVED WITH THE JUSTICE SYSTEM; AND THOSE RE-ENTERING THE COMMUNITY POST-INCARCERATION. ADDITIONALLY, NH WILL ADDRESS THE UNIQUE SERVICE NEEDS OF HISTORICALLY UNDERSERVED AND UNDERREPRESENTED POPULATIONS, INCLUDING BUT NOT LIMITED TO RACIAL AND ETHNIC MINORITY GROUPS AND INDIVIDUALS WHO HAVE COMMUNICATION ACCESS NEEDS. IN COORDINATION WITH ALL CURRENT STATE AND FEDERAL FUNDING, SOR INITIATIVES ACROSS NH CONTINUE TO ADDRESS ONGOING CHALLENGES AND COMPLEMENT MULTI-SECTOR EFFORTS ACROSS THE CONTINUUM. NH ANTICIPATES SERVING APPROXIMATELY 6,350 UNDUPLICATED INDIVIDUALS ANNUALLY. NH REQUESTS THE FULL FUNDING AVAILABLE, $29,880,604 ANNUALLY AND INTENDS TO USE THIS GRANT TO SUPPORT ACCESS TO CRITICAL SERVICES THAT ARE NOT ACCESSIBLE FOR POPULATIONS DUE TO INSURANCE COVERAGE BARRIERS, SERVICE CAPACITY GAPS, AND WORKFORCE SHORTAGES. EXAMPLES OF THESE SERVICES INCLUDE MEDICATIONS FOR SUBSTANCE USE DISORDER, PREVENTION MESSAGING, TRAINING, WORKFORCE READINESS OPPORTUNITIES, AND SUPPORT SERVICES THAT INCREASE TREATMENT INITIATION, ENGAGEMENT, AND RETENTION (CHILDCARE, TRANSPORTATION). NH WILL USE THE GOVERNMENT PERFORMANCE AND RESULTS ACT (GPRA) DATA COLLECTION AND NOTICE OF FUNDING OPPORTUNITY (NOFO) FOLLOW-UP REQUIREMENTS TO IDENTIFY THE OUTCOMES OF EACH INITIATIVE FUNDED WITH SOR RESOURCES TO INFORM SUSTAINABILITY PLANS. ALL OF THE PROJECTS PROPOSED MEET THE INTENT OF THE NOFO BY INCREASING ACCESS TO MEDICATIONS FOR SUBSTANCE USE DISORDERS, SUPPORTING THE CONTINUUM OF PREVENTION, HARM REDUCTION, TREATMENT, AND RECOVERY SUPPORT SERVICES FOR OUD AND OTHER CONCURRENT SUBSTANCE USE DISORDERS, AND SUPPORTS THE CONTINUUM OF CARE FOR O/STIMUD INCLUDING THOSE INVOLVING COCAINE AND METHAMPHETAMINE. | health |
| 2026-03-20 | DEPARTMENT OF HUMAN SERVICES COLORADO | Department of Health and Human Services | $60,590,323 | LIHEAP-2022 | social-services |
| 2026-04-06 | JAEB CENTER FOR HEALTH RESEARCH FOUNDATION, INC. | Department of Health and Human Services | $60,555,044 | PEDIATRIC EYE DISEASE INVESTIGATOR GROUP NETWORK | health |
| 2026-03-20 | PENNSYLVANIA DEPARTMENT OF DRUG AND ALCOHOL PROGRAMS | Department of Health and Human Services | $60,455,223 | SUBSTANCE ABUSE PREVENTION, TREATMENT, AND RECOVERY SERVICES BLOCK GRANT | health |
| 2026-04-22 | TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA, THE | Department of Health and Human Services | $60,372,420 | ALZHEIMER'S DISEASE GENETICS CONSORTIUM | biotech |
| 2026-04-06 | VALLEY-WIDE HEALTH SYSTEMS | Department of Health and Human Services | $60,277,668 | HEALTH CENTER CLUSTER | health |
| 2026-02-13 | INCENTIVE TECHNOLOGY GROUP LLC | Department of Health and Human Services | $60,266,468 | NCI CBIIT MISSION NEED FOR DIGITAL SUPPORT SERVICES. | health |
| 2026-03-20 | DEPARTMENT OF HUMAN SERVICES COLORADO | Department of Health and Human Services | $60,260,997 | LIHEAP-2021 | social-services |
| 2026-05-05 | COMMUNITY HEALTH CENTER OF LUBBOCK | Department of Health and Human Services | $60,247,257 | HEALTH CENTER CLUSTER | health |
| 2026-04-06 | SOCIAL SERVICES, VIRGINIA DEPARTMENT OF | Department of Health and Human Services | $60,216,116 | SCSS-2024 | social-services |
| 2026-04-06 | ILLINOIS DEPARTMENT OF HUMAN SERVICE | Department of Health and Human Services | $60,180,901 | SSBG-2023 | social-services |
| 2026-03-05 | BAKERRIPLEY | Department of Health and Human Services | $60,106,493 | HEAD START AND EARLY HEAD START | social-services |
| 2026-05-05 | UNIVERSITY OF OKLAHOMA | Department of Health and Human Services | $60,096,875 | OKLAHOMA SHARED CLINICAL AND TRANSLATIONAL RESOURCES | health |
| 2026-05-05 | BLUE RIDGE COMMUNITY HEALTH SERVICES, INC. | Department of Health and Human Services | $60,060,471 | HEALTH CENTER CLUSTER | health |
| 2026-03-20 | ALLIANCE FOR COMMUNITY EMPOWERMENT, INC. | Department of Health and Human Services | $59,992,040 | HEAD START AND EARLY HEAD START | social-services |
| 2026-03-20 | PUBLIC HEALTH, CALIFORNIA DEPARTMENT OF | Department of Health and Human Services | $59,970,118 | HIGH-IMPACT PREVENTION AND SURVEILLANCE PROGRAMS FOR HEALTH DEPARTMENTS - THIS APPLICATION IS FOR THE FIVE-YEAR FUNDING OPPORTUNITY ANNOUNCEMENT FOR HEALTH DEPARTMENTS TO IMPLEMENT AN INTEGRATED AND COMPREHENSIVE HIV SURVEILLANCE AND PREVENTION PROGRAM TO PREVENT NEW HIV INFECTIONS AND ACHIEVE VIRAL SUPPRESSION AMONG PERSONS LIVING WITH HIV. THIS PROJECT WILL PROMOTE AND SUPPORT IMPROVING HEALTH OUTCOMES FOR PERSONS LIVING WITH HIV THROUGH ACHIEVING AND SUSTAINING VIRAL SUPPRESSION. ACTIVITIES WILL FOCUS ON REDUCING HEALTH-RELATED DISPARITIES BY USING QUALITY, TIMELY, AND COMPLETE SURVEILLANCE AND PROGRAM DATA TO GUIDE HIV PREVENTION EFFORTS. THESE CORE ACTIVITIES CAN BE CONTAINED WITHIN TWO CATEGORIES: (1) PROGRAM PREVENTION; AND (2) PROGRAM SURVEILLANCE. HIV PREVENTION AND SURVEILLANCE PROGRAMS WILL FOCUS ON THE PREVENTION OF NEW HIV INFECTIONS TO IMPROVE THE HEALTH OF PEOPLE WITH HIV. THIS PROJECT WILL INTEGRATE THE WORK OF THE OFFICE OF AIDS’S (OA) HIV SURVEILLANCE AND PREVENTION EVALUATION AND REPORTING (SPER) BRANCH AND HIV PREVENTION BRANCH TO ADDRESS THE EMERGING SYNDEMIC OF HIV, HCV, AND STIS IN CALIFORNIA, AS OUTLINED IN THE 2022-2026 ENDING THE EPIDEMICS: ADDRESSING HIV, HCV, AND STIS IN THE CALIFORNIA STRATEGIC PLAN. THROUGH THIS PLAN, CALIFORNIA ADDRESSES HIV AS A SYNDEMIC WITH HCV AND OTHER STIS THOUGH A SOCIAL DETERMINANTS OF HEALTH LENS, HIGHLIGHTING: A) RACIAL EQUITY, B) HOUSING, C) ACCESS TO HEALTHCARE, D) MENTAL HEALTH AND SUBSTANCE USE, E) ECONOMIC JUSTICE, AND F) STIGMA. OA WILL IMBED THESE PRACTICES INTO SERVICE DELIVERY TO IMPROVE HEALTH EQUITY EFFORTS IN FUNDED JURISDICTIONS BY COORDINATING THESE APPROACHES TO HIV PREVENTION AND TREATMENT RESULTING IN POSITIVE HEALTH OUTCOMES FOR ALL. THE CALIFORNIA EHE PLAN WILL COORDINATE THE WORK OF SIX PHASE I EHE COUNTIES THROUGH 2029: BUILDING ON AND UPDATING THEIR EXISTING EHE PLANS ANNUALLY. THE SIX PHASE I COUNTIES COMPRISE THE CALIFORNIA CONSORTIUM: ALAMEDA, ORANGE, RIVERSIDE, SACRAMENTO, SAN BERNARDINO, AND SAN DIEGO. THE SIX COUNTIES ARE IN VARIOUS GEOGRAPHIC REGIONS AND HAVE DIFFERING PREVENTION NEEDS FOR THEIR DISTINCT POPULATIONS. THUS, CALIFORNIA WILL MAINTAIN AN EHE COORDINATOR AT THE STATE-LEVEL AS WELL AS IN EACH ONE OF THE SIX CALIFORNIA CONSORTIUM COUNTIES. THE WORK OF OUR EHE PLAN WILL: INCREASED LOCAL AVAILABILITY AND ACCESSIBILITY OF INNOVATIVE HIV TESTING SERVICES RESULTING IN INCREASED HIV SCREENING AND ANNUAL RESCREENING AMONG EHE PRIORITY POPULATIONS; BUILD THE CAPACITY FOR RAPID LINKAGE TO CARE, ART AND PREP IN A STATUS-NEUTRAL FRAMEWORK, TO BETTER SERVE EHE PRIORITY POPULATIONS AT THE INTERSECTION OF MENTAL HEALTH, SUBSTANCE USE AND HOUSING STATUS IN EHE COUNTIES; BUILD THE CAPACITY OF EHE COUNTIES TO USE NOVEL, EVIDENCED BASED APPROACHES TO LINK CLIENTS TO PREP/PEP; ENHANCE DATA TO CARE RESPONSE FOR EHE PRIORITY POPULATIONS; AND ENHANCE COMMUNITY ENGAGEMENT TO RECRUIT NEW VOICES AND NON-TRADITIONAL PARTNERS TO THE HIV/STIC/HCV PLANNING TABLE AND TO CONTINUOUSLY IMPROVE EHE INTERVENTIONS. | health |
| 2026-03-20 | CITY OF NEW YORK | Department of Health and Human Services | $59,969,557 | STRENGTHENING STD PREVENTION AND CONTROL FOR HEALTH DEPARTMENTS (STD PCHD). | health |
| 2026-04-06 | HEALTH SERVICES INC | Department of Health and Human Services | $59,923,758 | HEALTH CENTER CLUSTER | health |
| 2026-04-20 | HEALTH SERVICES KENTUCKY CABINET FOR | Department of Health and Human Services | $59,829,474 | RYAN WHITE CARE ACT TITLE II | health |
| 2026-04-06 | THE COMMONWEALTH OF MASSACHUSETTS | Department of Health and Human Services | $59,796,161 | SCSS-2024 | social-services |
| 2026-04-06 | UNIVERSITY OF ARIZONA | Department of Health and Human Services | $59,754,489 | PRECISION AGING NETWORK: CLOSING THE GAP BETWEEN COGNITIVE HEALTHSPAN ANDHUMAN LIFESPAN - SUMMARY/ABSTRACT: OVERALL PROJECT THE STRATEGIC VISION OF THE PRECISION AGING NETWORK (PAN) IS TO DEVELOP THE ESSENTIAL SCIENTIFIC KNOWLEDGE TO UNDERSTAND THE DISCREPANCY THAT CURRENTLY EXISTS BETWEEN COGNITIVE HEALTHSPAN AND HUMAN LIFESPAN. WE MUST REVEAL THE NEURAL MECHANISMS THAT 1) ACCOUNT FOR OPTIMAL BRAIN PERFORMANCE IN OLD AGE RESULTING IN HEALTHY COGNITIVE FUNCTION, AND 2) THOSE THAT UNDERLIE DECLINE IN BRAIN FUNCTION LEADING TO AGE-RELATED COGNITIVE IMPAIRMENT (ARCI), ALZHEIMER’S DISEASE (AD), OR ALZHEIMER’S DISEASE-RELATED DEMENTIAS (ADRD). THE ULTIMATE GOAL OF THE PAN IS TO DEVELOP NOT ONLY A STRONG SCIENTIFIC FOUNDATION FOR THE ESSENTIAL KNOWLEDGE NEEDED TO MATCH COGNITIVE HEALTHSPAN WITH HUMAN LIFESPAN, BUT ALSO TO LEVERAGE BIG DATA APPROACHES THAT APPLY PRECISION MEDICINE CONCEPTS TO PROLONG OPTIMAL BRAIN FUNCTION. TO ACHIEVE THIS GOAL OF SUSTAINING OPTIMAL COGNITIVE FUNCTION IN OLD AGE, AND TO EXTEND QUALITY OF LIFE FOR PEOPLE ACROSS LEVELS OF RISK FOR ARCI, AD, OR ADRD, WE MAINTAIN THAT METHODOLOGIES SUCH AS THOSE DEVELOPED AND IMPLEMENTED IN THE PAN WILL BE REQUIRED. ALTHOUGH ‘CHRONOLOGICAL AGE’ IS CONSISTENTLY ASSOCIATED WITH INCREASING INCIDENCE OF DISABILITY, INCLUDING CHRONIC BRAIN DISORDERS SUCH AS AD AND ADRD, THE EXACT MECHANISTIC RELATIONSHIPS BETWEEN ‘BIOLOGICAL AGE’ AND DECLINE IN BRAIN FUNCTION IS NOT KNOWN. THE NUMBER OF PEOPLE NOW LIVING WITH SOME FORM OF DEMENTIA IS ESTIMATED TO BE 50 MILLION WORLDWIDE, WHICH IS EXPECTED TO DOUBLE EVERY 20 YEARS. BECAUSE OF THE ENORMOUS HETEROGENEITY IN BRAIN AND COGNITIVE FUNCTION AMONG INDIVIDUALS IN THEIR 70S, 80S AND 90S, THE URGENT CHALLENGE FOR SCIENCE, MEDICINE AND HEALTHCARE PROVIDERS IS TO DISCOVER INTERVENTIONS THAT ARE INDIVIDUALLY EFFECTIVE IN DELAYING OR PREVENTING ARCI, AD, OR ADRD. UNTANGLING THE COMPLEX RELATIONSHIP BETWEEN AGE AND COGNITIVE PERFORMANCE REQUIRES A STRATEGY THAT INCLUDES THE STUDY OF VERY LARGE, DIVERSE, WELL-CHARACTERIZED AND LONGITUDINALLY SAMPLED POPULATIONS. THIS WILL REQUIRE ‘BIG DATA’ BUT ALSO THE MEANS TO TRANSLATE THE MASSIVE AMOUNTS OF INFORMATION GATHERED INTO ‘SMART DATA’ OR ‘KNOWLEDGE’. THIS DEMANDS RADICALLY DIFFERENT CONCEPTUAL MODELS. CURRENTLY, NO SINGLE APPROACH ADEQUATELY IDENTIFIES THE MEANS TO MODIFY PERSONAL AGING TRAJECTORIES FOR IMPROVED BRAIN HEALTH IN INDIVIDUALS. THE APPROACH PROPOSED IN PAN IS DESIGNED TO OVERCOME OBSTACLES OF EARLIER METHODS. THE FOCUS IS ON HOW TO DISTINGUISH THE VARIOUS COMBINATIONS OF AGE, SEX, GENETICS, RACE-ETHNICITY, HEALTH, LIFESTYLE CHOICES AND ENVIRONMENTAL FACTORS THAT INFLUENCE BRAIN DRIVERS THAT INCREASE SUSCEPTIBILITY TO DYSFUNCTION, AS WELL AS THOSE FACTORS THAT INCREASE BRAIN PROTECTION AND RESISTANCE AGAINST DYSFUNCTION. THE FUNDAMENTAL PRINCIPLE OF THE PRECISION MEDICINE APPROACH IS TO ’INDIVIDUALIZE’. THIS WILL ENABLE STRONG AND SPECIFIC PREDICTIONS FOR EACH PERSON TO CLOSE THE GAP BETWEEN COGNITIVE HEALTHSPAN AND HUMAN LIFESPAN. THE ROOT OF THIS CONCEPT IS IN THE TEACHINGS OF HIPPOCRATES, WHO SAID – “IT IS MORE IMPORTANT TO KNOW WHAT SORT OF PERSON HAS A DISEASE THAN TO KNOW WHAT SORT OF DISEASE A PERSON HAS.” | biotech |
| 2026-05-05 | ILLINOIS DEPARTMENT OF HUMAN SERVICE | Department of Health and Human Services | $59,734,536 | SSBG-2024 | social-services |
| 2026-05-05 | COUNTY OF LOS ANGELES | Department of Health and Human Services | $59,714,865 | COOPERATIVE AGREEMENT FOR EMERGENCY RESPONSE: PUBLIC HEALTH CRISIS RESPONSE - 2018 | health |
| 2026-04-20 | OHIO DEPARTMENT OF CHILDREN AND YOUTH | Department of Health and Human Services | $59,605,958 | CCDF-2026 - CHILD CARE AND DEVELOPMENT FUND MANDATORY & MATCHING | social-services |
| 2026-03-05 | HEALTH, WASHINGTON STATE DEPARTMENT OF | Department of Health and Human Services | $59,527,509 | PUBLIC HEALTH EMERGENCY PREPAREDNESS (PHEP) COOPERATIVE AGREEMENT CDC-RFA-TP19-1901 | health |
| 2026-04-20 | NORTH CAROLINA DEPARTMENT OF HEALTH & HUMAN SERVICES | Department of Health and Human Services | $59,515,321 | CCDM-2026 - CHILD CARE AND DEVELOPMENT FUND -- STATE MATCHING | social-services |
| 2026-03-20 | BARRIO COMPREHENSIVE FAMILY HEALTH CARE CENTER, INC. | Department of Health and Human Services | $59,477,901 | HEALTH CENTER CLUSTER | health |
| 2026-04-20 | NEBRASKA DEPARTMENT OF HEALTH & HUMAN SERVICES | Department of Health and Human Services | $59,404,452 | CDC-RFA-IP19-1901 IMMUNIZATION AND VACCINES FOR CHILDREN | health |
| 2026-02-27 | TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA, THE | Department of Health and Human Services | $59,273,750 | AWARD OF THE BASE TO UPENN FOR CEIRR CONTRACT 75N93021C00015. THIS CONTRACT WILL SUPPORT THE NIAID CENTERS OF EXCELLENCE FOR INFLUENZA RESEARCH AND RESPONSE (CEIRR) | biotech |
| 2026-04-06 | DEPARTMENT OF HUMAN SERVICES COLORADO | Department of Health and Human Services | $59,242,103 | LIHEAP-2024 | social-services |
| 2026-04-20 | NORTH CAROLINA DEPARTMENT OF HEALTH & HUMAN SERVICES | Department of Health and Human Services | $59,193,344 | CCDF-2026 - CHILD CARE AND DEVELOPMENT FUND MANDATORY & MATCHING | social-services |
| 2026-05-05 | BOTSWANA-UNIVERSITY OF MARYLAND SCHOOL OF MEDICINE HEALTH INITIATIVES | Department of Health and Human Services | $59,144,763 | ACCELERATING BOTSWANA THROUGH THE LAST MILE TO EPIDEMIC CONTROL (ABLE) PROJECT | health |
| 2026-04-06 | HEALTH SERVICES KENTUCKY CABINET FOR | Department of Health and Human Services | $59,142,078 | LIHEAP-2024 | social-services |
| 2026-04-20 | HEALTH AND HUMAN RESOURCES, WEST VIRGINIA DEPARTMENT OF | Department of Health and Human Services | $59,079,065 | CDC-RFA-IP19-1901 IMMUNIZATION AND VACCINES FOR CHILDREN | health |
| 2026-03-20 | HEALTH SERVICES KENTUCKY CABINET FOR | Department of Health and Human Services | $59,037,115 | LIHEAP-2023 | social-services |
| 2026-04-20 | LOS ANGELES COUNTY OFFICE OF EDUCATION | Department of Health and Human Services | $58,995,834 | EARLY HEAD START CHILDCARE PARTNERSHIP | social-services |
| 2026-03-20 | DEPARTMENT OF HUMAN SERVICES COLORADO | Department of Health and Human Services | $58,911,548 | LIHEAP-2023 | social-services |
| 2026-05-05 | NORTH EAST MEDICAL SERVICES | Department of Health and Human Services | $58,854,310 | HEALTH CENTER CLUSTER | health |
| 2026-04-20 | COMMUNITY HEALTH ASSOCIATION OF SPOKANE | Department of Health and Human Services | $58,755,889 | HEALTH CENTER CLUSTER | health |
| 2026-04-20 | LVCT HEALTH | Department of Health and Human Services | $58,724,520 | VUKISHA 95:TRANSITIONING COMPREHENSIVE HIV PROGRAMS TO COUNTIES TO ACHIEVE UNAIDS 95-95-95 GOALS | health |
| 2026-05-05 | JWCH INSTITUTE, INC. | Department of Health and Human Services | $58,721,228 | HEALTH CENTER CLUSTER | health |
| 2026-02-17 | SERVEFED INC. | Department of Health and Human Services | $58,712,173 | CLINICAL EAST OCCUPATIONAL HEALTH SUPPORT SERVICES | health |
| 2026-05-05 | PCC COMMUNITY WELLNESS CENTER | Department of Health and Human Services | $58,676,935 | HEALTH CENTER CLUSTER | health |
| 2026-04-06 | NEBRASKA DEPARTMENT OF HEALTH & HUMAN SERVICES | Department of Health and Human Services | $58,549,977 | FOSTER-2026 - FOSTER CARE | social-services |
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