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Federal awards
Every contract and grant ingested from USAspending.gov. Pick an agency to narrow the list; toggle Highest / Lowest to sort. Click any row to open the full award profile.
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Agency: Department of Health and Human ServicesStatus: Currently active
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1,077 awards
Showing 951–1000
| Action date | Recipient | Agency | Amount | Description | Sector |
|---|---|---|---|---|---|
| 2026-04-24 | REGENTS OF THE UNIVERSITY OF CALIFORNIA, SAN FRANCISCO, THE | Department of Health and Human Services | $40,678,119 | NOVATION FROM CPIC TO UCSF EFFECT. 8/01/18--SURVEILLANCE, EPIDEMIOLOGY, AND END RESULTS (SEER) PROGRAM, POP: 05/01/2018-04/30/2028 | health |
| — | KANSAS DEPARTMENT OF HEALTH & ENVIRONMENT | Department of Health and Human Services | $40,625,875 | CDC-RFA-OE22-2203, STRENGTHENING U.S. PUBLIC HEALTH INFRASTRUCTURE, WORKFORCE, AND DATA SYSTEMS - STRATEGIC INVESTMENTS THROUGH OE22-2203 FUNDING WILL HELP MEET SHORT-TERM CRITICAL INFRASTRUCTURE NEEDS AND HAVE LASTING EFFECTS ON THE KANSAS PUBLIC HEALTH SYSTEM. THROUGH THIS FUNDING, THE KANSAS DEPARTMENT OF HEALTH AND ENVIRONMENT (KDHE) WILL STRENGTHEN PUBLIC HEALTH INFRASTRUCTURE AND SYSTEMS RELATED TO HIRING, RETAINING, SUSTAINING AND TRAINING THE WORKFORCE, ENHANCING FOUNDATIONAL CAPABILITIES, AND DEPLOYING A ROBUST DATA INFRASTRUCTURE. A1 WORKFORCE: AS RECOMMENDED IN THE NOTICE OF FUNDING OPPORTUNITY, KDHE WILL DEDICATE SIGNIFICANT FUNDING WITHIN STRATEGY 1 TO HIRING, RETAINING, SUSTAINING AND TRAINING STAFF. THE AGENCY WILL FILL VACANCIES, CREATE NEW POSITIONS, AND RETAIN STAFF THROUGH INCREASING EDUCATIONAL OPPORTUNITIES AND EQUITABLE PAY AS WELL AS SUPPORTING STAFF WITH INCREASED FOCUS ON BEHAVIORAL HEALTH CARE, AND TRAINING STAFF THROUGH PROVISION OF ROBUST LEARNING OPPORTUNITIES IN RESPONSE TO WORKFORCE ASSESSMENT NEEDS. THESE ACTIVITIES WILL ACHIEVE THE SHORT-TERM OUTCOME OF INCREASED HIRING OF DIVERSE STAFF AS WELL AS IMPROVING ORGANIZATIONAL PROCESSES AND SYSTEMS. A2 FOUNDATIONAL CAPABILITIES: STRATEGY 2 ACTIVITIES WILL SUPPORT IMPROVED OVERALL SYSTEMS, PROCESSES AND POLICIES TO ENSURE A STRONG CORE INFRASTRUCTURE NEEDED TO PROTECT HEALTH AND PROVIDE FAIR OPPORTUNITIES FOR ALL. KEY ACTIVITIES ARE NOT LIMITED TO: STRENGTHENING ACCOUNTABILITY THROUGH ACCREDITATION SUPPORT, STRENGTHENING INFORMATION TECHNOLOGY ORGANIZATIONAL COMPETENCIES THROUGH LOCAL HEALTH DEPARTMENT ELECTRONIC HEALTH RECORD SYSTEM IMPLEMENTATION, AND STRENGTHENING COMMUNITY PARTNERSHIPS AND IMPROVING EQUITY IN LEADERSHIP THROUGH LOCAL POLICYMAKER TRAINING TO HELP ACHIEVE IMPROVED ORGANIZATIONAL SYSTEMS AND PROCESSES AND LEAD TO STRONGER FOUNDATIONAL CAPABILITIES IN THE PUBLIC HEALTH SYSTEM. ALONGSIDE INVESTMENTS AND ACTIONS IN STRATEGY 1, KANSAS WILL ACHIEVE AN INCREASED SIZE AND CAPABILITIES OF THE PUBLIC HEALTH WORKFORCE. A3 DATA MODERNIZATION: THE PROPOSED DATA MODERNIZATION INITIATIVE (DMI) WILL CREATE MODERN, INTEROPERABLE AND REAL-TIME PUBLIC HEALTH DATA AND SURVEILLANCE SYSTEMS FOR KANSAS THAT WILL BETTER PROTECT THE HEALTH OF THE AMERICAN PUBLIC. KDHE’S GOAL FOR STRATEGY A3 IS TO ENHANCE THE DATA AND INFORMATION INFRASTRUCTURE USED BY KANSAS PUBLIC HEALTH TO MAXIMIZE THE EFFICIENCY AND EFFECTIVENESS OF SERVICES PROVIDED TO ALL KANSANS. KDHE ACTIVITIES WILL INCLUDE IDENTIFYING AND HIRING A DATA MODERNIZATION DIRECTOR AND SUPPORTING IMPLEMENTATION STAFF; REVIEW AND UPDATE THE RECENT DATA MODERNIZATION ASSESSMENT COMPLETED; CREATE IMPLEMENTATION PLANS FOR MODERNIZING THE KANSAS PUBLIC HEALTH DATA ENVIRONMENT AND ADDRESSING DMI WORKFORCE NEEDS; AND IMPLEMENT THE PLANS THAT WILL CREATE DATA INFRASTRUCTURE ENHANCEMENTS AND IMPROVEMENTS. ADDITIONALLY, KDHE WILL ACCELERATE IMPLEMENTATION BY PROPOSING AN INNOVATIVE MODERNIZATION APPROACH THAT ENHANCE DATA QUALITY, EXCHANGE, DISSEMINATION AND USE. THE RESULTS WILL BE A MODERNIZED AND EFFICIENT DATA ENVIRONMENT PROVIDING INCREASED DATA INTEROPERABILITY AND GREATER ACCESS TO, AND USE OF, PUBLIC HEALTH DATA. THE SYSTEM DEVELOPED AND DEPLOYED WILL USE SCALABLE, FLEXIBLE, AND SUSTAINABLE TECHNOLOGIES, POLICIES AND METHODS TO IMPLEMENT THE MOST UP-TO-DATE DATA AND ANALYTICAL CAPABILITIES SO THAT KANSAS PUBLIC HEALTH CAN PROVIDE THE ESSENTIAL PUBLIC HEALTH SERVICES. REAL-TIME DATA WILL INFORM WORKFORCE EFFORTS, INCREASE EFFECTIVE DECISION-MAKING AND IMPROVE THE OVERALL EFFECTIVENESS OF KANSAS PUBLIC HEALTH. THE AGENCY WILL LEVERAGE CURRENT SUPPLEMENTAL FUNDING FOR DATA MODERNIZATION TO EXPAND WORKFORCE, LAB SYSTEM AND DATA-RELATED PROGRESS MADE THUS FAR TO ENHANCE DATA INTEROPERABILITY AND EFFICIENCY. THROUGH ACCOMPLISHING BOTH SHORT AND INTERMEDIATE TERM OUTCOMES, THE PUBLIC HEALTH SYSTEM IN KANSAS WILL HAVE ACCELERATED PREVENTION, PREPAREDNESS AND RESPONSE TO EMERGING THREATS AND MORE POSITIVE HEALTH OUTCOMES FOR ALL KANSANS. | health |
| — | HOUSING & COMMUNITY SERVICES, OREGON DEPARTMENT OF | Department of Health and Human Services | $40,482,105 | LIHEAP-2026 - LOW INCOME HOME ENERGY ASSISTANCE | social-services |
| — | UNIVERSITY OF CALIFORNIA IRVINE | Department of Health and Human Services | $40,410,179 | UNIV.OF CALIF., IRVINE CANCER CENTER SUPPORT GRANT | biotech |
| — | LONE STAR CIRCLE OF CARE | Department of Health and Human Services | $40,337,571 | HEALTH CENTER CLUSTER | health |
| — | THE FOUNDATION FOR AIDS RESEARCH | Department of Health and Human Services | $40,336,583 | THE ASIA-PACIFIC HIV OBSERVATIONAL DATABASE (APHOD) | health |
| — | ALABAMA REGIONAL MEDICAL SERVICES | Department of Health and Human Services | $40,329,283 | HEALTH CENTER CLUSTER | health |
| — | EXCELLENCE COMMUNITY EDUCATION WELFARE SCHEME (ECEWS) | Department of Health and Human Services | $40,201,538 | SUSTAINABLE PROGRAMS FOR HIV EPIDEMIC CONTROL AND EQUITABLE SERVICE DELIVERY (SPEED) - EXCELLENCE COMMUNITY EDUCATION WELFARE SCHEME (ECEWS), AN INDIGENOUS NIGERIAN ORGANIZATION, PROPOSES TO LEAD A CONSORTIUM TO SUPPORT 5 SOUTH WEST STATES OF LAGOS, OYO, OGUN, ONDO AND OSUN STATES IN THEIR PUSH TOWARD SUSTAINABLE HIV EPIDEMIC CONTROL. THE CONSORTIUM ALSO HAS THE GEOGRAPHICAL SPREAD TO INTERVENE IN ALL 19 CDC SUPPORTED STATES. THE CONSORTIUM PARTNERS INCLUDE ACHIEVING HEALTH NIGERIA INITIATIVE (AHNI), ASSOCIATION OF REPRODUCTIVE FAMILY HEALTH (ARFH), FHI 360 (TECHNICAL ASSISTANCE PARTNER) AND HOWARD UNIVERSITY GLOBAL INITIATIVE IN NIGERIA (HUGIN) (TECHNICAL ASSISTANCE PARTNER). THE ECEWS LED CONSORTIUM WILL ASSIST THE FIVE STATES OF LAGOS, OGUN, ONDO, OYO AND OSUN ACHIEVE TREATMENT SATURATION AND SUSTAINED EPIDEMIC CONTROL, ESPECIALLY THE LOCAL GOVERNMENT AREAS (LGA) WITH THE HIGHEST UNMET NEED FOR ANTIRETROVIRAL THERAPY (ART). THE ECEWS-LED CONSORTIUM IS WELL-PLACED TO NOT ONLY MAINTAIN THESE SIGNIFICANT GAINS BUT ALSO HAS THE SKILLS AND EXPERIENCE TO IDENTIFY THE NEARLY 115, 803 HIV+ INDIVIDUALS WHO REMAIN UNDIAGNOSED ACROSS THE FIVE STATES WITH A SPECIFIC FOCUS ON LGAS SUCH AS ALIMOSHO AND KOSOFE IN LAGOS AND OTHER LGAS ACROSS THE 5 STATES THAT HAVE THE HIGHEST PLHIV BURDEN AND LOW TREATMENT COVERAGE. ECEWS, THE PRIME AND THE LEAD SERVICE DELIVERY PARTNER IN LAGOS, OGUN AND OYO STATE. AHNI, THE LEAD FOR SERVICE DELIVERY IN OSUN AND ONDO. ARFH, THE LEAD FOR ORPHANED AND VULNERABLE CHILDREN (OVC) ACROSS ALL STATES. FHI 360 WILL BE THE LEAD TECHNICAL ASSISTANCE (TA) PROVIDER FOR M&E/STRATEGIC INFORMATION, HEALTH INFORMATICS, SURVEILLANCE, AND LABORATORY SERVICES. HUGIN WILL PROVIDE VALUABLE EXPERTISE FOR DIFFERENTIATED SERVICE DELIVERY (DSD) INCLUDING DECENTRALIZATION OF ART IN THE PRIVATE SECTOR AND STRENGTHEN PUBLIC AND PRIVATE PHARMACY SYSTEMS. THE ECEWS CONSORTIUM PROPOSES A GRANULAR DATA-DRIVEN APPROACH TO IMPROVE ON CURRENT STRATEGIES, SATURATE THE FIVE TARGET STATES AND ACHIEVE SUSTAINABLE HIV EPIDEMIC CONTROL. WE HAVE ORGANIZED THE WORK PLAN USING THE RESULTS CDC PROVIDED: INTERMEDIATE OUTCOME 1: INCREASED COVERAGE OF ART AMONG PLHIV, INTERMEDIATE OUTCOME 2: INCREASED UPTAKE OF HIV TESTING, DIAGNOSIS AND LINKAGE FOR HIGH- RISK PERSONS AND UNDERSERVED POPULATIONS ACROSS ALL AGES, SEXES, AND GEOGRAPHIC LOCATIONS, INTERMEDIATE OUTCOME 3: INCREASED UPTAKE OF EVIDENCE-BASED HIV PREVENTION SERVICES FOR AT-RISK POPULATIONS, INTERMEDIATE OUTCOME 4: IMPROVED CLINICAL MANAGEMENT OF HIV THROUGH UTILIZATION OF DIAGNOSTIC SERVICES TO OPTIMIZE PATIENT CARE, INTERMEDIATE OUTCOME 5: IMPROVED UTILIZATION OF PATIENT-LEVEL HIV SERVICE DELIVERY DATA FOR CONTINUOUS QUALITY IMPROVEMENT (CQI) AND INTERMEDIATE OUTCOME 6: INCREASED FINANCIAL AND PROGRAMMATIC OWNERSHIP BY THE STATE GOVERNMENT AND CIVIL SOCIETY ORGANIZATIONS (CSOS) TO LEAD AND MANAGE COMPREHENSIVE HIV PROGRAMS. TO ATTAIN THESE RESULTS, OUR APPROACH WILL BE TECHNOLOGY DRIVEN, INNOVATIVE, INCLUSIVE, CONTEXT-SPECIFIC, EVIDENCE-BASED AND CLIENT-CENTERED PREVENTION AND TREATMENT SERVICES; ROBUST COMMUNITY ENGAGEMENT; COLLABORATION WITH STATE GOVERNMENT AGENCIES, CSOS AND PRIVATE SECTOR; DATA USE FOR DECISION-MAKING AND SCALE-UP OF INTERVENTIONS; LEVERAGE EXISTING INVESTMENTS, RESOURCES AND RESULTS AND EMPOWERMENT OF STATE AND LOCAL ACTORS TO ACCELERATE SUSTAINABILITY. EVALUATION AND PERFORMANCE MEASUREMENT PLAN (EPMP). THE PROJECT’S RIGOROUS EPMP WILL SEAMLESSLY STRENGTHEN M&E SYSTEMS AT STATE, LGA, FACILITY AND COMMUNITY LEVELS. WE WILL CONTINUE ENHANCING GOVERNMENT OWNERSHIP OF M&E STRUCTURES AND SYSTEMS, INCLUDING DATA UTILIZATION. THE M&E SYSTEM WILL BE RESPONSIVE TO EMERGING DATA REQUIREMENTS ACCORDING TO THE MONITORING, EVALUATION AND REPORTING (MER) GUIDANCE, ENSURE QUALITY ASSESSMENTS AND IMPROVEMENTS AS GUIDED BY THE SITE IMPROVEMENT THROUGH MONITORING SYSTEM (SIMS) AND ENSURE ROUTINE QUARTERLY REPORTING TO THE DONOR THROUGH THE DATA FOR ACCOUNTABILITY AND TRANSPARENCY AND | health |
| — | CITY OF NORFOLK | Department of Health and Human Services | $40,158,554 | HIV EMERGENCY RELIEF PROJECT GRANTS | health |
| — | HUMAN SERVICES, OKLAHOMA DEPT OF | Department of Health and Human Services | $40,120,968 | LIHEAP-2026 - LOW INCOME HOME ENERGY ASSISTANCE | social-services |
| — | CASE WESTERN RESERVE UNIVERSITY | Department of Health and Human Services | $39,950,893 | CASE AIDS CLINICAL TRIALS UNIT | health |
| — | ST JUDE CHILDREN'S RESEARCH HOSPITAL INC | Department of Health and Human Services | $39,949,612 | PEDIATRIC BRAIN TUMOR CONSORTIUM (PBTC) | health |
| — | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK | Department of Health and Human Services | $39,949,463 | STRENGTHENING REGIONAL, NATIONAL, AND SUBNATIONAL INSTITUTIONAL CAPACITIES TO SUSTAINABLY COMBAT HIV/AIDS AND TUBERCULOSIS UNDER THE PRESIDENT'S EMERGENCY PLAN FOR AIDS RELIEF (PEPFAR) | health |
| 2026-05-07 | SEMANTICBITS LLC | Department of Health and Human Services | $39,852,046 | CMMI ANALYSIS AND MANAGEMENT SYSTEM (AMS) DEVELOPMENT | health |
| — | CHILD START, INC. | Department of Health and Human Services | $39,848,308 | HEAD START AND EARLY HEAD START | social-services |
| — | ELIZABETH GLASER PEDIATRIC AIDS FOUNDATION | Department of Health and Human Services | $39,834,060 | ELIZABETH GLASER PEDIATRIC AIDS FOUNDATION - IMPLEMENTATION OF COMPREHENSIVE PROGRAMS FOR THE PREVENTION, CARE, AND TREATMENT OF HIV/AIDS IN THE REPUBLIC OF COTE D'IVOIRE UNDER PEPFAR - THE ELIZABETH GLASER PEDIATRIC AIDS FOUNDATION (EGPAF) IS PLEASED TO PRESENT OUR APPROACH FOR THE U.S. CENTERS FOR DISEASE CONTROL AND PREVENTION’S (CDC) IMPLEMENTATION OF COMPREHENSIVE PROGRAMS FOR THE PREVENTION, CARE, AND TREATMENT OF HIV/AIDS IN THE REPUBLIC OF CÔTE D’IVOIRE UNDER THE PRESIDENT’S EMERGENCY PLAN FOR AIDS RELIEF (PEPFAR) (SOLICITATION NUMBER CDC-RFA-GH22-2237). EGPAF WILL LEVERAGE ITS IN-DEPTH KNOWLEDGE OF THE HIV EPIDEMIC IN CÔTE D’IVOIRE, STRONG RELATIONSHIPS AND COLLABORATIONS WITH IN-COUNTRY STAKEHOLDERS, AND RECOGNIZED EXPERTISE IN HIV PREVENTION, CARE, AND TREATMENT TO REACH AND SUSTAIN THE UNAIDS 95-95-95 TARGETS. EGPAF, IN PARTNERSHIP WITH HEARTLAND ALLIANCE CÔTE D’IVOIRE (HACI) AND CENTRE SOLIDARITE ACTION SOCIALE (CSAS), WILL INCREASE THE SUSTAINABILITY OF CÔTE D’IVOIRE’S HIV/AIDS RESPONSE THROUGH PROVISION OF COMPREHENSIVE HIV PREVENTION, CARE, AND TREATMENT SERVICES, AND TECHNICAL ASSISTANCE (TA) TO THE MINISTRY OF HEALTH, PUBLIC HYGIENE, AND UNIVERSAL HEALTH PROTECTION (MSHPCMU), REGIONAL AND DISTRICT HEALTH MANAGEMENT TEAMS, AND LOCAL COMMUNITY-BASED ORGANIZATIONS AND FACILITIES TO DELIVER QUALITY HIV/AIDS SERVICES AND SUSTAIN EPIDEMIC CONTROL. EGPAF WILL PROVIDE LEADERSHIP AND SUPPORT TO ACTIVITIES ACROSS ALL PROGRAM AREAS THROUGH DIRECT SERVICE DELIVERY AND TA. HACI WILL OFFER KEY POPULATION SPECIFIC SERVICES, INCLUDING DEMAND CREATION FOR HIV SERVICES; COMMUNITY COUNSELLING, TESTING, AND TREATMENT REFERRAL; GENDER-BASED VIOLENCE; SCREENING AND RESPONSE; AND PSYCHOSOCIAL SUPPORT. CSAS WILL SUPPORT DELIVERY OF HIV AND OTHER HEALTH SERVICES, AS WELL AS ECONOMIC STRENGTHENING, TARGETING ADOLESCENT GIRLS AND YOUNG WOMEN (AGYW) AND ORPHANS AND VULNERABLE CHILDREN (OVC) BENEFICIARIES. THE PROJECT WILL IMPLEMENT STRATEGIC ACTIVITIES IN ALIGNMENT WITH FOUR CROSS-CUTTING APPROACHES: IMPLEMENT COORDINATED FACILITY- AND COMMUNITY-BASED STRATEGIES TO DELIVERY HIGH-QUALITY SERVICES TO TARGET POPULATIONS; GENERATE AND USE HIGH QUALITY DATA AND A ROBUST QUALITY IMPROVEMENT (QI) APPROACH; BUILD CAPACITY OF THE MSHPCMU AND LOCAL ORGANIZATIONS TO ENSURE THE SUCCESSFUL TRANSITION OF PREVENTION, CARE, AND TREATMENT SERVICES; AND PROMOTE PERSON-CENTERED AND INNOVATIVE INTERVENTIONS TO MITIGATE BARRIERS TO SERVICE DELIVERY. THE PROJECT WILL BE LED BY EGPAF’S HIGHLY RESPECTED LEADERSHIP TEAM. COUNTRY DIRECTOR/PRINCIPAL INVESTIGATOR DR. CHARLES JOSEPH DIBY WILL PROVIDE STRATEGIC AND MANAGERIAL LEADERSHIP AS THE PRIMARY POINT OF CONTACT FOR CDC, THE MSHPCMU, AND OTHER STAKEHOLDERS, BUILDING ON HIS EXPERIENCE LEADING THE CURRENT PROJECT DJASSO. TECHNICAL DIRECTOR DR. KOUADIO MARC N’GORAN WILL ENSURE THE IMPLEMENTATION OF HIGH-QUALITY HIV/AIDS INTERVENTIONS WITH FIDELITY, OVERSEE EFFORTS TO STRENGTHEN COMMUNITY-FACILITY LINKAGES, AND LEAD TRAINING AND CAPACITY BUILDING ACTIVITIES. STRATEGIC INFORMATION DIRECTOR N’DA N’GUESSAN JEAN-PAUL KOUADIO WILL OVERSEE THE PROJECT’S STRATEGIC INFORMATION AND EVALUATION (SI&E) PROGRAM, INCLUDING MONITORING AND EVALUATION (M&E), INFORMATICS, AND DATA USE. FINANCE DIRECTOR ALFRED ZIE OUATTARA WILL OVERSEE PROJECT FINANCES, SUB-AWARDS, AND ADMINISTRATION, INCLUDING BUDGET OVERSIGHT, PROCUREMENT, AND REPORTING TO CDC. THEY WILL BE SUPPORTED BY EXISTING EGPAF STAFF, 100% OF WHOM ARE IVOIRIAN AND SPEAK FRENCH AND LOCAL LANGUAGES. A KEY PARTNER IN CÔTE D’IVOIRE SINCE 2004, EGPAF WAS THE FIRST ORGANIZATION TO SUPPORT THE SCALE-UP OF PREVENTION OF MOTHER-TO-CHILD TRANSMISSION (PMTCT) IN COUNTRY, AND HAS BEEN A TRUSTED PARTNER TO THE MSHPCMU AT EACH STAGE OF THE HIV RESPONSE. TOGETHER, THE PROJECT TEAMS’ EXPERIENCE AND FAMILIARITY WITH THE IVOIRIAN CONTEXT, DEPTH OF EXPERTISE, AND ABILITY TO DRAW ON TOOLS AND BEST PRACTICES FROM CÔTE D’IVOIRE AND GLOBALLY MAKE US UNIQUELY QUALIFIED TO ACHIEVE THE PROJECT GOAL. | health |
| — | HEALTH RESEARCH, INC. | Department of Health and Human Services | $39,741,151 | NYS/HRI PUBLIC HEALTH EMERGENCY PREPAREDNESS (PHEP) COOPERATIVE AGREEMENT | health |
| — | TRUSTEES OF BOSTON UNIVERSITY | Department of Health and Human Services | $39,687,209 | NOVEL INSIGHTS INTO OSTEOARTHRITIS, PAIN AND FUNCTION: MOST4 - OVERALL ABSTRACT THE MULTICENTER OSTEOARTHRITIS (MOST) STUDY HAS BEEN A MAJOR SOURCE OF NEW KNOWLEDGE ABOUT THE COURSE OF OA AND FACTORS THAT AFFECT IT, HAVING PUBLISHED OVER 180 ARTICLES RANGING FROM STUDIES OF PAIN AND PAIN SENSITIZATION, TO INVESTIGATIONS OF BIOMECHANICS, TO INQUIRIES INTO STRUCTURAL JOINT PATHOLOGY AS VISUALIZED BY MRI, AND TO STUDIES OF DECLINE IN FUNCTION, BUCKLING AND FALLS, AMONG OTHERS. THE INITIAL COHORT ENROLLED 3026 PARTICIPANTS WITH OR AT RISK OF KNEE OA; A NEW COHORT CONSISTING OF 1525 SUBJECTS WAS RECRUITED AT THE LAST CYCLE (MOST3) WHO WERE SLIGHTLY YOUNGER AND UNLIKELY TO HAVE ADVANCED DISEASE. WE WILL RECRUIT AN ADDITIONAL 150 PARTICIPANTS FROM UNDERREPRESENTED MINORITY GROUPS FOR A TOTAL PROJECTED SAMPLE SIZE OF 2293 IN THIS NEXT CYCLE OF MOST (MOST4). IN ADDITION TO ITS SCIENTIFIC OUTPUT, THE STUDY HAS BEEN REMARKABLE IN RECRUITING AND ENCOURAGING TALENTED YOUNG INVESTIGATORS TO TAKE ON CAREER DEFINING INVESTIGATIONS WITHIN MOST, HAVING SERVED AS THE BASIS FOR 31 CAREER DEVELOPMENT AWARDS. OUR OVERALL GOAL IS TO ADVANCE OUR UNDERSTANDING OF OA AND ITS CONSEQUENCES TO OPEN DOORS TO NEW TREATMENT APPROACHES INCLUDING STRATIFIED APPROACHES TO TREATMENTS. WE WILL USE AN INTEGRATED APPROACH IN THE NEXT CYCLE OF MOST (MOST4) OVERSEEN BY AN ADMINISTRATIVE CORE, INVOLVING A CLINICAL DATA COLLECTION AND MANAGEMENT CORE, ANALYSIS CORE, AND IMAGING CORE, WITH GUIDANCE FROM AN OBSERVATIONAL SAFETY MONITORING BOARD AND INPUT FROM A COMMUNITY ADVISORY BOARD, TO EFFICIENTLY ADDRESS KEY KNOWLEDGE GAPS THROUGH THE CONDUCT OF THREE PROJECTS. OUR SPECIFIC AIMS ARE TO: 1. EVALUATE IMPAIRED EXERCISE-INDUCED HYPOALGESIA (EIH) IN KNEE OA, EVALUATE THE RELATION OF NERVOUS SYSTEM ALTERATIONS TO EIH, AND DETERMINE THE IMPACT OF EIH ON PAIN, FUNCTION, PHYSICAL ACTIVITY, AND FEAR-AVOIDANCE RELATED TO EXERCISE (PROJECT 1); 2. CARRY OUT PROTEOMICS ANALYSIS OF SYNOVIAL FLUID TO DETERMINE NETWORKS OF PROTEINS ASSOCIATED WITH GENERALIZED VS. LOCALIZED OA, PAIN AND DISEASE PROGRESSION (PROJECT 2); 3. DIFFERENTIATE TYPES OF CALCIUM CRYSTALS DEPOSITED IN THE JOINT AND, FOR EACH OF THEM, UNDERSTAND THE CLINICAL AND STRUCTURAL CONSEQUENCES OF CRYSTAL DEPOSITION (PROJECT 3); 4. TAKE ADVANTAGE OF COMPREHENSIVE LONGITUDINAL DATA ALREADY COLLECTED IN MOST TO ADDRESS A WIDE RANGE OF QUESTIONS RELATED TO OA AND ITS IMPACT ON OUTCOMES; 5. BRING A MULTIDISCIPLINARY APPROACH TO BEAR ON THIS COMPLEX DISEASE AND OFFER CAREER DEVELOPMENT OPPORTUNITIES TO INVESTIGATORS INCLUDING PILOT PROJECT GRANTS IN THIS UNDERSTUDIED CONDITION. MOST4 WILL INTRODUCE NEW APPROACHES TO UNDERSTANDING DISEASE AND WILL CONTINUE TO COMPREHENSIVELY ASSESS PAIN, STRUCTURAL, AND FUNCTIONAL OUTCOMES SO THAT THE SPECIFIC EFFECTS OF THE FACTORS PROPOSED IN THE PROJECTS AND OTHER RISK FACTORS CAN BE EXAMINED. THIS WORK WILL PRODUCE NEW ACTIONABLE INSIGHTS REGARDING PAIN, STRUCTURAL DETERIORATION AND FUNCTION LOSS IN KNEE OA. | health |
| — | ACCESS HEALTH LOUISIANA | Department of Health and Human Services | $39,549,155 | HEALTH CENTER CLUSTER | health |
| 2026-04-30 | PERATON INC. | Department of Health and Human Services | $39,444,251 | DATA USE CLUSTER | health |
| — | CENTRO SAN VICENTE | Department of Health and Human Services | $39,362,527 | HEALTH CENTER CLUSTER | health |
| — | PAPA OLA LOKAHI | Department of Health and Human Services | $39,215,559 | HEALTH CARE FOR NATIVE HAWAIIANS | health |
| 2026-05-08 | INVIRSA, INC. | Department of Health and Human Services | $38,965,983 | INV-102 FOR THE TREATMENT OF MUSTARD GAS KERATOPATHY UNDER BAA-18-100-SOL-00003, AREA OF INTEREST 5.3. | health |
| — | EDWARD M KENNEDY COMMUNITY HEALTH CENTER, INC | Department of Health and Human Services | $38,890,855 | HEALTH CENTER CLUSTER | health |
| — | EAST ARKANSAS FAMILY HEALTH CENTER, INC. | Department of Health and Human Services | $38,880,262 | HEALTH CENTER CLUSTER | health |
| — | THE COMMUNITY CLINIC, INC. | Department of Health and Human Services | $38,877,492 | HEALTH CENTER CLUSTER | health |
| — | COMMUNITY HEALTH ALLIANCE | Department of Health and Human Services | $38,826,937 | HEALTH CENTER CLUSTER | health |
| — | ADVOCATES FOR A HEALTHY COMMUNITY INC | Department of Health and Human Services | $38,815,359 | HEALTH CENTER CLUSTER | health |
| — | GRACE HEALTH, INC | Department of Health and Human Services | $38,467,547 | HEALTH CENTER CLUSTER | health |
| — | KANSAS DEPARTMENT FOR CHILDREN AND FAMILIES | Department of Health and Human Services | $38,443,565 | LIHEAP-2026 - LOW INCOME HOME ENERGY ASSISTANCE | social-services |
| 2026-04-27 | FRED HUTCHINSON CANCER CENTER | Department of Health and Human Services | $38,272,655 | IGF::OT::IGF CORE INFRASTRUCTURE SUPPORT FOR SURVEILLANCE, EPIDEMIOLOGY, AND END RESULTS (SEER) | health |
| 2026-03-11 | MONOGRAM BIOSCIENCES, INC. | Department of Health and Human Services | $38,008,679 | HIGH THROUGHPUT SARS-COV-2 NEUTRALIZING ANTIBODY IMMUNOASSAY FOR QUALIFYING VARIANTS AND TESTING OF HUMAN SERUM SAMPLES. | biotech |
| — | CENTRAL CITY COMMUNITY HEALTH CENTER, INC | Department of Health and Human Services | $37,956,509 | HEALTH CENTER CLUSTER | health |
| — | UNIVERSITY OF PUERTO RICO MEDICAL SCIENCES CAMPUS | Department of Health and Human Services | $37,946,246 | CARIBBEAN PRIMATE RESEARCH CENTER | biotech |
| 2026-04-02 | ACCENTURE FEDERAL SERVICES LLC | Department of Health and Human Services | $37,757,771 | ACCENTURE SECURITY CONTRACT-FFP LABORPERIOD OF PERFORMANCE: 3/11/2023 - 3/12/2024 | health |
| — | COMMUNITY HEALTH CARE, INC. | Department of Health and Human Services | $37,748,506 | HEALTH CENTER CLUSTER | health |
| 2026-05-08 | LEIDOS BIOMEDICAL RESEARCH INC | Department of Health and Human Services | $37,727,154 | CPTAC BIOSPECIMEN COLLECTION | biotech |
| — | BRAZOS VALLEY COMMUNITY ACTION AGENCY, INC. | Department of Health and Human Services | $37,654,503 | HEALTH CENTER CLUSTER | health |
| — | UNIVERSIDAD DEL VALLE DE GUATEMALA | Department of Health and Human Services | $37,652,320 | SCALING UP HIGH-IMPACT HIV PREVENTION, TESTING AND TREATMENT MODELS IN CENTRAL AMERICA UNDER THE PRESIDENT'S EMERGENCY PLAN FOR AIDS RELIEF (PEPFAR) | health |
| 2026-03-17 | GENENTECH USA, INC | Department of Health and Human Services | $37,485,000 | PROCURENT OF XOFLUZA (BALOXAVIR MARBOXIL) 40MG AND 80MG TABLETS | health |
| 2026-04-28 | DATA COMPUTER CORPORATION OF AMERICA | Department of Health and Human Services | $37,406,511 | THE CENTERS FOR MEDICAID AND MEDICAID SERVICES (CMS), AN OPERATIONAL DIVISION (OPDIV) OF THE DEPARTMENT OF HEALTH AND HUMAN SERVICES (HHS), IS RESPONSIBLE FOR ENSURING HEALTH CARE COVERAGE FOR MORE THAN 100 MILLION AMERICANS THROUGH MEDICARE, MEDICAI | health |
| — | PROJECT HEALTH, INC. | Department of Health and Human Services | $37,304,479 | HEALTH CENTER CLUSTER | health |
| — | KEYSTONE RURAL HEALTH CENTER | Department of Health and Human Services | $37,281,617 | HEALTH CENTER CLUSTER | health |
| — | IDAHO DEPARTMENT OF HEALTH & WELFARE | Department of Health and Human Services | $37,281,052 | CCDD-2026 - CHILD CARE AND DEVELOPMENT BLOCK GRANT DISCRETIONARY | social-services |
| — | INSPIRE DEVELOPMENT CENTERS | Department of Health and Human Services | $37,188,240 | EARLY HEAD START | social-services |
| — | COMMUNITY COUNCIL OF IDAHO, INC | Department of Health and Human Services | $37,028,575 | MIGRANT AND SEASONAL HEAD START AND EARLY HEAD START | social-services |
| — | INSTITUTE FOR HEALTH MEASUREMENT | Department of Health and Human Services | $37,007,832 | STRENGTHENING CAPACITY FOR HEALTH INFORMATION SYSTEMS SUSTAINABILITY | health |
| — | BALDWIN FAMILY HEALTH CARE | Department of Health and Human Services | $36,953,951 | HEALTH CENTER CLUSTER | health |
| — | BOSTON MOUNTAIN RURAL HEALTH CENTER, INC | Department of Health and Human Services | $36,687,986 | HEALTH CENTER CLUSTER | health |
| 2026-03-27 | BECKMAN COULTER, INC | Department of Health and Human Services | $36,655,675 | THE OVERALL OBJECTIVE OF THIS CONTRACT IS TO DEVELOP AND COMMERCIALIZE A RAPID PHENOTYPIC ANTIMICROBIAL SUSCEPTIBILITY TESTING (AST) SYSTEM THAT WILL DELIVER RESULTS FOR DEFINITIVE THERAPEUTIC DECISIONS WITHIN 4 TO 6 HOURS FROM COLONIES ON A CULTURE | health |
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